(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine → HCID 11589165, compound

HRID 2261212Notes

Reaction equation

HRID 2261212 reaction equation
CO[C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][C:5]=1[F:11].Cl[CH2:14][C:15]1[CH:19]=[CH:18][S:17][CH:16]=1.[NH:20]1[CH2:24][CH2:23][CH2:22][C@H:21]1[CH2:25][N:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1>>[F:11][C:5]1[CH:6]=[C:7]([O:10][CH2:14][C:15]2[CH:19]=[CH:18][S:17][CH:16]=2)[CH:8]=[CH:9][C:4]=1[C:3]([N:20]1[CH2:24][CH2:23][CH2:22][C@H:21]1[CH2:25][N:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1)=[O:12]

Participants

4

Reactant 3

HCID 853152(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidineHCID 124874623-(Chloromethyl)thiopheneHCID 22463192Methyl 2-fluoro-4-hydroxybenzoate

Product 1

HCID 11589165HCID 11589165, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedures D and E using 2-fluoro-4-hydroxy-benzoic acid methyl ester [CAS 197507-22-5], 3-chloromethyl-thiophene [CAS 2746-23-8], and (S)(+)-1-(2-pyrrolidinylmethyl)pyrrolidine. MS (ES+) m/e 389.2

Sources & evidence

ORD record
ord-dde6a5648f5d4c4ea57f99eeb05c5e1d
Source dataset
uspto-grants-2010_12
Patent number
US07846950B2

Reaction notes

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