2-(Chloromethyl)thiophene → HCID 11668522, compound

HRID 2261215Notes

Reaction equation

HRID 2261215 reaction equation
CO[C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][C:5]=1[F:11].Cl[CH2:14][C:15]1[S:16][CH:17]=[CH:18][CH:19]=1.[CH3:20][C@@H:21]1[CH2:25][CH2:24][CH2:23][N:22]1[CH2:26][C@@H:27]1[CH2:31][CH2:30][CH2:29][NH:28]1>>[F:11][C:5]1[CH:6]=[C:7]([O:10][CH2:14][C:15]2[S:16][CH:17]=[CH:18][CH:19]=2)[CH:8]=[CH:9][C:4]=1[C:3]([N:28]1[CH2:29][CH2:30][CH2:31][C@H:27]1[CH2:26][N:22]1[CH2:23][CH2:24][CH2:25][C@H:21]1[CH3:20])=[O:12]

Participants

4

Reactant 3

HCID 698302-(Chloromethyl)thiopheneHCID 22463192Methyl 2-fluoro-4-hydroxybenzoateHCID 46911921(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine

Product 1

HCID 11668522HCID 11668522, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedures D and E using 2-fluoro-4-hydroxy-benzoic acid methyl ester [CAS 197507-22-5], 2-chloromethyl-thiophene [CAS 2746-23-8], and 2-(R)-methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine. MS (ES+) m/e 403.3

Sources & evidence

ORD record
ord-9a6c7798aca34ce9b3f399399cc25d24
Source dataset
uspto-grants-2010_12
Patent number
US07846950B2

Reaction notes

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