4-(Bromomethyl)thiophene-2-carbonitrile → 4-{3-Fluoro-4-[2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidine-1-carbonyl]-phenoxymethyl}-thiophene-2-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	4-(Bromomethyl)thiophene-2-carbonitrile	HCID 10750607	—
Reactant	(2-Fluoro-4-hydroxy-phenyl)-[2-(S)(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone	HCID 11960537	—
Product	4-{3-Fluoro-4-[2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidine-1-carbonyl]-phenoxymethyl}-thiophene-2-carbonitrile	HCID 11711605	—

Reaction Steps

The title compound is prepared in a manner substantially analogous to Procedure C from (2-Fluoro-4-hydroxy-phenyl)-[2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone and 4-bromomethyl-thiophene-2-carbonitrile [CAS 186552-07-8]. MS (ES+) m/e 428.3

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07846950B2
Source dataset	uspto-grants-2010_12
ORD ID	ord-d0df42da6fdf46058725a206e97c28fc
Source note	uspto-grants-2010_12