4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid → HCID 66930006, compound

HRID 2261227Notes

Reaction equation

HRID 2261227 reaction equation
Cl.Cl.[CH:3]([N:6]1[CH2:12][CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)([CH3:5])[CH3:4].[CH3:13][C:14]1([CH3:30])[C:18]([CH3:20])([CH3:19])[O:17][B:16]([C:21]2[CH:29]=[CH:28][C:24]([C:25](O)=[O:26])=[CH:23][CH:22]=2)[O:15]1>>[CH:3]([N:6]1[CH2:12][CH2:11][CH2:10][N:9]([C:25]([C:24]2[CH:23]=[CH:22][C:21]([B:16]3[O:17][C:18]([CH3:20])([CH3:19])[C:14]([CH3:30])([CH3:13])[O:15]3)=[CH:29][CH:28]=2)=[O:26])[CH2:8][CH2:7]1)([CH3:5])[CH3:4]

Participants

3

Reactant 2

HCID 27346214-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acidHCID 455958001-isopropyl-1,4-diazepane dihydrochloride

Product 1

HCID 66930006HCID 66930006, compound

Procedure

The tile compound (D12) was prepared in a similar manner to Description 7 from 1-(isopropyl)-hexahydro-1H-1,4-diazepine (free base of D2) and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid and isolated as a brown oil. LCMS electrospray (+ve) 373 (MH+).

Workup

  1. customisolated as a brown oil

Sources & evidence

ORD record
ord-97266cfab6d34c0382925b5a3cc1e4b0
Source dataset
uspto-grants-2010_12
Patent number
US07846922B2

Reaction notes

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