HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]benzoic Acid → 1-Cyclobutyl-4-({4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]phenyl}carbonyl) hexahydro-1H-1,4-diazepine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]benzoic Acid | HCID 1483707 | — |
| Reactant | 1-Cyclobutyl-1,4-diazepane dihydrochloride | HCID 57423952 | — |
| Product | 1-Cyclobutyl-4-({4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]phenyl}carbonyl) hexahydro-1H-1,4-diazepine hydrochloride | HCID 66930266 | — |
Reaction Steps
The title compound (E8) was prepared from 1-(cyclobutyl)-hexahydro-1H-1,4-diazepine dihydrochloride (D4) and 4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]benzoic acid using the procedure described in Example 7. MS APCl 436 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07846922B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-4f533d3742b0459e8e69c77167de43d1 |
| Source note | uspto-grants-2010_12 |