HCID 68774908, compound → HCID 57543438, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-(2-chloro-5-iodophenyl)-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one (60 mg, 0.12 mmol) and copper(I) cyanide (54 mg, 0.6 mmol) in DMF (1.5 mL) were heated in a microwave at 140° C. for 1 h. LC-MS indicates ˜60% conversion to the desired product. Additional copper(I) cyanide (100 mg) was added and the reaction mixture was heated for another 1 h in the microwave at 140° C. The reaction mixture was diluted in DCM (20 mL), washed with brine (2×15 mL), dried over MgSO4, filtered and concentrated. The crude residue was purified on the ISCO 12 g column (15-50% EtOAc in hexanes) affording the title compound as a white amorphous solid. MS (ESI, pos.ion) m/z: 397.0 (M+1).

Provenance & Evidence