tert-Butanol → HCID 68739684, compound

Participants

Reaction Steps

A solution of 7-allyl-5-bromo-1-(2,4-difluorophenyl)-1H-pyrazolo[3,4-b]pyridin-6(7H)-one (265 mg, 0.724 mmol) in tert-BuOH (5 mL) and water (5 mL) at RT was treated with 4-methylmorpholine N-oxide (127 mg, 1.09 mmol) and potassium osmate dihydrate (10 mg, 0.027 mmol). The resulting mixture was allowed to stir for 16 h at RT, then diluted with an aqueous solution of sodium sulfite (10 mL) and extracted with EtOAc (3×25 mL). The organic extracts were dried over MgSO4, filtered and concentrated. The crude residue was purified on the ISCO 12 g column (0-5% MeOH:DCM) affording the title compound as a white amorphous solid. MS (ESI, pos.ion) m/z: 399.0/401.0 (M+1).

Provenance & Evidence