Thionyl Chloride → HCID 14674299, compound

HRID 2261288Notes

Reaction equation

HRID 2261288 reaction equation
[C:1]([C:5]1[CH:9]=[C:8]([CH2:10]O)[O:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].S(Cl)([Cl:14])=O>ClCCl>[C:1]([C:5]1[CH:9]=[C:8]([CH2:10][Cl:14])[O:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 12920232HCID 12920232, compound

Product 1

HCID 14674299HCID 14674299, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.12 g of (3-t-butyl-isoxazol-5-yl)methanol was dissolved in 35 ml of dichloromethane, and 2.4 ml of thionyl chloride was added. The mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure. The residue was washed with hexane to obtain 1.12 g of 3-t-butyl-5-(chloromethyl)-isoxazole.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. washThe residue was washed with hexane

Sources & evidence

ORD record
ord-356e4e5682644567a3388782d38711a5
Source dataset
uspto-grants-2010_12
Patent number
US07846956B2

Reaction notes

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