HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 5-(tert-Butyl)-3-(chloromethyl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (5-Tert-butyl-1,2-oxazol-3-yl)methanol | HCID 10820794 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-(tert-Butyl)-3-(chloromethyl)isoxazole | HCID 55265215 | — |
Reaction Steps
0.62 g of (5-t-butyl-isoxazol-3-yl)methanol was dissolved in 12 ml of dichloromethane, and 0.9 ml of thionyl chloride was added. The mixture was stirred at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure to obtain 0.69 g of 5-t-butyl-3-(chloromethyl)isoxazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07846956B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-70328621ac6d43a49d57e011c3009733 |
| Source note | uspto-grants-2010_12 |