Thionyl Chloride → 4-(Chloromethyl)-2-(2-propynyloxy)-thiazole

Participants

Reaction Steps

0.20 g of [2-(2-propynyloxy)-thiazol-4-yl]methanol was dissolved in 5 ml of chloroform, and 0.2 g of thionyl chloride was added. The mixture was heated to reflux for 1 hour. The reaction mixture was cooled to room temperature and then concentrated under reduced pressure to obtain 0.30 g of 4-(chloromethyl)-2-(2-propynyloxy)-thiazole.

Provenance & Evidence