Malononitrile → HCID 86631041, compound

HRID 2261304Notes

Reaction equation

HRID 2261304 reaction equation
[CH2:1]([O:4][C:5]1[S:6][C:7]([CH:10]=O)=[CH:8][N:9]=1)[C:2]#[CH:3].[C:12](#[N:16])[CH2:13][C:14]#[N:15]>O.C(O)C>[CH2:1]([O:4][C:5]1[S:6][C:7]([CH:10]=[C:13]([C:12]#[N:16])[C:14]#[N:15])=[CH:8][N:9]=1)[C:2]#[CH:3]

Participants

5

Reactant 2

HCID 8010MalononitrileHCID 577363172-(2-Propyn-1-yloxy)-5-thiazolecarboxaldehyde

Product 1

HCID 86631041HCID 86631041, compoundYield 86%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

1.4 g of 2-(2-propynyloxy)-1,3-thiazole-5-carbaldehyde was dissolved in a mixture of 6 ml of water and 14 ml of ethanol, and 0.56 g of malononitrile was added dropwise. The mixture was stirred at room temperature for 3 hours. Thereafter, the reaction mixture was filtered, and the resulting cake was washed with 5 ml of ethanol two times and dried under reduced pressure to obtain 1.55 g of {[2-(2-propynyloxy)-1,3-thiazol-5-yl]methylidene}malononitrile.

Workup

  1. additionwas added dropwise
  2. filtrationThereafter, the reaction mixture was filtered
  3. washthe resulting cake was washed with 5 ml of ethanol two times
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-c7a8deba48c442868d845d129ad82ec8
Source dataset
uspto-grants-2010_12
Patent number
US07846956B2

Reaction notes

Loading…