Thionyl Chloride → HCID 68776252, compound

HRID 2261307Notes

Reaction equation

HRID 2261307 reaction equation
[C:1]([C:5]1[N:9]=[C:8]([CH2:10]O)[S:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].S(Cl)([Cl:14])=O>ClCCl>[ClH:14].[C:1]([C:5]1[N:9]=[C:8]([CH2:10][Cl:14])[S:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 57736333HCID 57736333, compound

Product 1

HCID 68776252HCID 68776252, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.71 g of 3-t-butyl-5-hydroxymethyl-1,2,4-thiadiazole was dissolved in 20 ml of dichloromethane, and 1.4 ml of thionyl chloride was added. The mixture was stirred at room temperature for 4 hours. The reaction mixture was concentrated under reduced pressure to obtain 0.76 g of 3-t-butyl-5-(chloromethyl)-1,2,4-thiadiazole hydrochloride.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-4456e86583b74c9d9e0d977db7cd52ad
Source dataset
uspto-grants-2010_12
Patent number
US07846956B2

Reaction notes

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