HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon tetrabromide → 861135-68-4
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon tetrabromide | HCID 11205 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 3-Isoxazolemethanol,5-(trifluoromethyl)-(9CI) | HCID 15365200 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 861135-68-4 | HCID 57736368 | 33.5% |
Reaction Steps
2.47 g of (5-trifluoromethyl-isoxazol-3-yl)methanol was dissolved in 80 ml of diethyl ether, and 6.56 g of triphenylphosphine and 8.9 g of carbon tetrabromide were then added. The mixture was stirred at room temperature for 1 hour. The reaction mixture was subjected to silica gel column chromatography to obtain 1.14 g of 3-(bromomethyl)-5-trifluoromethylisoxazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07846956B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-11e19dca3f704f609044ec36d8cb4281 |
| Source note | uspto-grants-2010_12 |