(5-Tert-butyl-1,2-oxazol-3-yl)methanol → 5-(Tert-butyl)isoxazole-3-carbaldehyde

Participants

Reaction Steps

1.35 g of (5-t-butyl-isoxazol-3-yl)methanol was dissolved in 50 ml of 1,4-dioxane, and 6.42 g of manganese dioxide was then added. The mixture was stirred and heated under reflux for 10 hours. The reaction mixture was cooled to room temperature and then filtered through Celite®. The filtrate was concentrated under reduced pressure to obtain 1.29 g of 5-t-butyl-isoxazole-3-carbaldehyde.

Provenance & Evidence