Thionyl Chloride → 861135-78-6

HRID 2261349Notes

Reaction equation

HRID 2261349 reaction equation
[F:1][C:2]([C:5]1[O:9][N:8]=[C:7]([CH2:10]O)[CH:6]=1)([F:4])[CH3:3].S(Cl)([Cl:14])=O>ClCCl>[Cl:14][CH2:10][C:7]1[CH:6]=[C:5]([C:2]([F:4])([F:1])[CH3:3])[O:9][N:8]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 57736322HCID 57736322, compound

Product 1

HCID 57736391861135-78-6

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.00 g of [5-(1,1-difluoroethyl)isoxazol-3-yl]methanol was dissolved in 10 ml of dichloromethane, and 0.8 ml of thionyl chloride was then added. The mixture was stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure to obtain 1.11 g of 3-(chloromethyl)-5-(1,1-difluoroethyl)isoxazole.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-0efb0f9c87d84c039ee6dd93e702874c
Source dataset
uspto-grants-2010_12
Patent number
US07846956B2

Reaction notes

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