alpha5,alpha5-Dimethyl-3,5-isoxazoledimethanol → 5-(2-Hydroxypropan-2-yl)isoxazole-3-carbaldehyde

Participants

Reaction Steps

5.38 g of [5-(1-hydroxy-1-methylethyl)isoxazol-3-yl]methanol was dissolved in 100 ml of 1,4-dioxane, and 29.74 g of manganese dioxide was then added. The mixture was stirred and heated under reflux for 10 hours. The reaction mixture was cooled to room temperature and then filtered through Celite®. The filtrate was concentrated under reduced pressure to obtain 4.63 g of 5-(1-hydroxy-1-methylethyl)-isoxazole-3-carbaldehyde.

Provenance & Evidence