Thionyl Chloride → HCID 57736386, compound

HRID 2261360Notes

Reaction equation

HRID 2261360 reaction equation
[CH3:1][C:2]([C:8]1[O:12][N:11]=[C:10]([CH2:13]O)[CH:9]=1)([O:4][CH2:5][C:6]#[CH:7])[CH3:3].S(Cl)([Cl:17])=O>ClCCl>[Cl:17][CH2:13][C:10]1[CH:9]=[C:8]([C:2]([CH3:3])([O:4][CH2:5][C:6]#[CH:7])[CH3:1])[O:12][N:11]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 57736326HCID 57736326, compound

Product 1

HCID 57736386HCID 57736386, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.20 g of {5-[1-methyl-1-(2-propynyloxy)ethyl]isoxazol-3-yl}methanol was dissolved in 5 ml of dichloromethane, and 0.5 ml of thionyl chloride was then added. The mixture was stirred at room temperature for 3 hours. The reaction mixture was concentrated under reduced pressure to obtain 0.21 g of 3-(chloromethyl)-5-[1-methyl-1-(2-propynyloxy)ethyl]isoxazole.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-620532568c8f44e28062fb5ab23dc71d
Source dataset
uspto-grants-2010_12
Patent number
US07846956B2

Reaction notes

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