Thionyl Chloride → 5-(Chloromethyl)-3-methoxy-1,2-oxazole

HRID 2261363Notes

Reaction equation

HRID 2261363 reaction equation
[CH3:1][O:2][C:3]1[CH:7]=[C:6]([CH2:8]O)[O:5][N:4]=1.S(Cl)([Cl:12])=O>ClCCl>[Cl:12][CH2:8][C:6]1[O:5][N:4]=[C:3]([O:2][CH3:1])[CH:7]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 106782583-Methoxy-5-isoxazolemethanol

Product 1

HCID 100805435-(Chloromethyl)-3-methoxy-1,2-oxazole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.55 g of (3-methoxyisoxazol-5-yl)methanol was dissolved in 30 ml of dichloromethane, and 2 ml of thionyl chloride was then added. The mixture was stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure to obtain 1.30 g of 5-(chloromethyl)-3-methoxyisoxazole.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-34a66417c5ec4ca4a731d514b97630a2
Source dataset
uspto-grants-2010_12
Patent number
US07846956B2

Reaction notes

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