Acetic Acid → HCID 59305559, compound

Participants

Reaction Steps

90 mg of 3-[1-(4-nitro-benzyl)-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-propionic acid methyl ester (0.3 mmol) was dissolved in methanol solution at room temperature. And then 290 mg of Zn (4.44 mmol) and 0.02 ml of acetic acid (0.3 mmol) were added thereto and the mixture was stirred for 48 hrs at room temperature. The resulting compound was purified by Silica gel column chromatography with ethylacetate as an eluant to give 20 mg of 3-[1-(4-amino-benzyl)-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-propionic acid methyl ester (h) (yield: 25%).

Provenance & Evidence