Acetic Acid → HCID 11164862, compound

Participants

Reaction Conditions

Reaction Steps

7 mg of compound (i) prepared by the above Step 2 was dissolved in methanol solution (0.02 mmol) and then 1.7 M methanolic suspension solution containing NH2OK (0.4 ml, 0.68 mmol) was added thereto at 0° C. and the resulting mixture was stirred for 8 hrs at room temperature. The resulting mixture was neutralized with 0.01 ml of acetic acid, diluted with 10% methanol/chloroform solution, filtered and concentrated in vacuo. The resulting compound was purified by Silica gel column chromatography with a solvent mixture mixed with methanol and chloroform (1:9) as an eluant to give 3.2 mg of N-{4-[3-(2-hydroxycarbamoyl-ethyl)-2-oxo-2,5-dihydro-pyrrole-1-yl-methyl]-phenyl}-benzamide (j) (yield: 46%).

Provenance & Evidence