反应详情

234 mg of 3-(allyl-benzyl-carbamoyl)-but-3-enoic acid methyl ester (o) (0.1 mmol) prepared by the above Step 1 was added to the catalyst solution containing 36 mg of Grubb's (I) catalyst (0.04 mmol) such as ruthenium dissolved in CH2Cl2 under Ar atmosphere. Then the mixture was stirred for 24 hrs at room temperature, filtered and concentrated in vacuo. The resultant was purified by Silica gel column chromatography with a solvent mixture mixed with EtOAc and hexanes (1:2) as an eluant to give 180 mg of (1-benzyl-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-acetic acid methyl ester (p) (yield: 85%).

1. additionwas added to the catalyst solution
2. filtrationfiltered
3. concentrationconcentrated in vacuo
4. customThe resultant was purified by Silica gel column chromatography with a solvent mixture
5. additionmixed with EtOAc and hexanes (1:2) as an eluant