4-Methylbenzaldehyde → Methyl 3-(4-methylphenyl)-2-propenoate

Participants

Reaction Conditions

Reaction Steps

1.0 g of p-tolualdehyde (8.3 mmol) and 4.16 g of triphenyl phosphanyliden-acetic acid methyl ester (12.45 mmol) were dissolved in methylene chloride, the reaction solution was stirred at 90° C. for overnight. After the resulting mixture was concentrated under reduced pressure, a solvent mixture mixed with EtOAc and hexane (1:7) was added thereto with stirring for 1 hr. And then white solid was removed on filter, the residue was filtered and concentrated in vacuo to give 1.39 g of 3-p-tolyl-acrylic acid methyl ester (40aa) (yield: 95%).

Provenance & Evidence