Sodium Methoxide → HCID 11854858, compound

HRID 2261461Notes

Reaction equation

HRID 2261461 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:14][CH2:15][C:16]([C:18]2[S:25][C:24]([CH3:26])=[C:23]3[C:19]=2[CH2:20][C@H:21]2[C:27]([CH3:29])([CH3:28])[C@H:22]23)=[O:17])[CH:5]=[C:6]([CH3:13])[C:7]=1[O:8][CH2:9][CH:10]1[CH2:12][O:11]1.[CH3:30][O-:31].[Na+]>CO>[OH:11][CH:10]([CH2:12][O:31][CH3:30])[CH2:9][O:8][C:7]1[C:6]([CH3:13])=[CH:5][C:4]([CH2:14][CH2:15][C:16]([C:18]2[S:25][C:24]([CH3:26])=[C:23]3[C:19]=2[CH2:20][C@H:21]2[C:27]([CH3:28])([CH3:29])[C@H:22]23)=[O:17])=[CH:3][C:2]=1[CH3:1]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 72793829HCID 72793829, compound

Product 1

HCID 11854858HCID 11854858, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-[4-(2-Hydroxy-3-methoxy-propoxy)-3,5-dimethyl-phenyl]-1-((1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalen-4-yl)-propan-1-one is prepared by treating 3-(3,5-dimethyl-4-oxiranylmethoxy-phenyl)-1-((1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalen-4-yl)-propan-1-one with sodium methylate in methanol at 65° C. for 16 h in analogy to the procedure given in Example 99; LC-MS: tR=1.10 min, [M+1]+=443.18.

Sources & evidence

ORD record
ord-cde7ddf02e4e4e1c9410a0050a992176
Source dataset
uspto-grants-2010_12
Patent number
US07846964B2

Reaction notes

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