Trimethylamine → Indoline, 1-(2-(4-pyridyl)ethyl)-

HRID 2261497Notes

Reaction equation

HRID 2261497 reaction equation
[OH-].[Na+].[CH3:3][CH2:4][CH:5]([CH:7](NC([C@H]1O[C@@H]1C(O)=O)=O)[C:8]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14]N)=O)[CH3:6].C[N:26]([CH3:28])C>O>[CH2:13]1[C:12]2[C:11](=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:10]([CH2:8][CH2:7][C:5]2[CH:4]=[CH:3][N:26]=[CH:28][CH:6]=2)[CH2:14]1

Participants

5

Reactant 3

HCID 1146TrimethylamineHCID 14798Sodium HydroxideHCID 101946933HCID 101946933, compound

Product 1

HCID 25056Indoline, 1-(2-(4-pyridyl)ethyl)-

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Another core-shell polymer, according to the present invention, was prepared by combining 200 g of SP-1 with 533 g of demineralized water and adjusting the pH to 10 with sodium hydroxide. The mixture was combined with 267 g of CPI-2 and stirred for 30 minutes. 59.1 g of trimethylamine (25% aq.) were added and allowed to stir for one hour. After one hour, the pH was raised to 12 and the mixture was vacuum distilled for 3 hours to remove residual trimethylamine.

Workup

  1. customwas prepared
  2. stirringto stir for one hour
  3. waitAfter one hour
  4. temperaturethe pH was raised to 12
  5. distillationdistilled for 3 hours
  6. customto remove residual trimethylamine

Sources & evidence

ORD record
ord-ed2d412eb0504b7390f004de5cbfe877
Source dataset
uspto-grants-2010_12
Patent number
US07847027B2

Reaction notes

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