Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | HCID 11357963 | HCID 11357963 | — |
| Solvent | Hexane | HCID 8058 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 11298655 | HCID 11298655 | 92% |
Reaction Steps
280 mg (1.0 mmol) of 2-(3-methanesulfonyloxypropoxy)naphthalene and 456 mg (3.0 mmol) of cesium fluoride are added to a solvent of 4.0 mL of t-butanol. The reaction mixture is stirred for 6 hrs at 80° C. 7 mL of ethyl ether is added to the reaction mixture to remove metal salts. After filtration, the filtrate is concentrated by reduced pressure distiller. 188 mg (92% yield) of 2-(3-fluoropropoxy)naphthalene is obtained by column chromatography (ethyl acetate:n-hexane=1:20).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07847092B2 |
|---|
| Source dataset | uspto-grants-2010_12 |
|---|
| ORD ID | ord-8262b4ceef6b4cafba49ff8811681d2f |
|---|
| Source note | uspto-grants-2010_12 |
|---|
