Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 2-Methyl-2-butanol | HCID 6405 | — |
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | HCID 86621610 | HCID 86621610 | — |
| Solvent | Hexane | HCID 8058 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 11298655 | HCID 11298655 | 93% |
Reaction Steps
356 mg (1.0 mmol) of 2-(3-toluenesulfonyloxypropoxy)naphthalene and 456 mg (3.0 mmol) of cesium fluoride are added to 4.0 mL of t-amyl alcohol in a reaction vessel. The reaction mixture is stirred for 2 hrs at 90° C. 7 mL of ethyl ether is added to remove metal salt. After filtration, the filtrate is concentrated by a reduced pressure distiller. 190 mg (93% yield) of 2-(3-fluoropropoxy)naphthalene is obtained by column chromatography (ethyl acetate:n-hexane=1:20).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07847092B2 |
|---|
| Source dataset | uspto-grants-2010_12 |
|---|
| ORD ID | ord-34f767da45f24f22988fbbd272417582 |
|---|
| Source note | uspto-grants-2010_12 |
|---|
