HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenylphosphinomethyl-pyrrolidine → Mitiglinide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenylphosphinomethyl-pyrrolidine | HCID 10209545 | — |
| Reactant | 2-Benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid | HCID 54571848 | — |
| Product | Mitiglinide | HCID 121891 | — |
Reaction Steps
The preparation was carried out in the same manner as in Example 1, except that 2.92 mg of BPPM was used instead of 3.02 mg of PCPPM of Example 1. After the reaction, the residual ratio of 2-benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid was 10.85%, and the optical purity of mitiglinide thus obtained was 96.1% e.e.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07847107B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-bb6f6adbe4b0476c81f9ff7f69d2ea12 |
| Source note | uspto-grants-2010_12 |