HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2261582Generated: November 2, 2026
Sodium hydride → (1H-pyrrolo[2,3-b]pyridin-3-yl)-[6-(3-trifluoromethyl-benzyloxy)-pyridin-3-yl]-methanone
https://huagongshe.com/reaction/2261582
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-(Trifluoromethyl)benzylic alcohol | HCID 67681 | — |
| Reactant | (6-Chloro-pyridin-3-yl)-(1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone | HCID 57588066 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (1H-pyrrolo[2,3-b]pyridin-3-yl)-[6-(3-trifluoromethyl-benzyloxy)-pyridin-3-yl]-methanone | HCID 59593361 | — |
Reaction Steps
To (6-Chloro-pyridin-3-yl)-(1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone 7 in DMSO was added (3-trifluoromethyl-phenyl)-methanol 72. Sodium hydride was added and the reaction was heated to 60° C. for two hours. The reaction was quenched with water and extracted with ethyl acetate. The organic portion was dried with magnesium sulfate and concentrated to provide (1H-pyrrolo[2,3-b]pyridin-3-yl)-[6-(3-trifluoromethyl-benzyloxy)-pyridin-3-yl]-methanone 73, which was used in the next step without additional purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07846941B2 |
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| Source dataset | uspto-grants-2010_12 |
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| ORD ID | ord-be51be55aea84101b06a6e343f2089b9 |
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| Source note | uspto-grants-2010_12 |
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