HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetic Acid → 2-[(Carboxymethyl)amino]pyridine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetic Acid | HCID 300 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-Aminonicotinic acid | HCID 72930 | — |
| Product | 2-[(Carboxymethyl)amino]pyridine-3-carboxylic acid | HCID 59593329 | — |
Reaction Steps
2-(Carboxymethyl-amino)-nicotinic acid 501 is prepared by reacting commercially available 2-Amino-nicotinic acid 500 with 2-chloroacetic acid in the presence of base (e.g. sodium carbonate) typically at room temperature for 1-4 hours followed by purification and isolation by conventional means (e.g. acid base extraction and recrystallization).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07846941B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-b23b26c4d19f4c67b1400f1900cde2ba |
| Source note | uspto-grants-2010_12 |