Acetate → 1-(3-Hydroxy-pyrrolo[2,3-b]pyridin-1-yl)-ethanone

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Reaction Steps

1-(3-Hydroxy-pyrrolo[2,3-b]pyridin-1-yl)-ethanone 503 is prepared from acetic acid 1-acetyl-1H-pyrrolo[2,3-b]pyridin-3-yl ester 502 by selective removal of the acetate at the 3-position by reaction with sodium in methanol at room temperature typically for 30 minutes to one hour, followed by purification and isolation by conventional means (e.g. extraction and recrystallization).

Provenance & Evidence