HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2261613Generated: October 29, 2026
Nitric Acid → 3-Nitro-1H-pyrrolo[2,3-b]pyridine
https://huagongshe.com/reaction/2261613
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | 1H-Pyrrolo(2,3-b)pyridine | HCID 9222 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Nitro-1H-pyrrolo[2,3-b]pyridine | HCID 13295896 | — |
Reaction Steps
3-nitro-7-azaindole 504 is prepared by adding 7-azaindole 1 to fuming nitric acid while cooling (e.g. 0° C.). After stirring for one to several hours, water is carefully added and the mixture neutralized with saturated sodium bicarbonate. The solids are collected by filtration and dried to provide 3-nitro-7-azaindole 504.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07846941B2 |
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| Source dataset | uspto-grants-2010_12 |
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| ORD ID | ord-1027350a444c46258b8064a316302465 |
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| Source note | uspto-grants-2010_12 |
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