Formaldehyde → Benzyl(methoxymethyl)((trimethylsilyl)methyl)amine

Participants

Reaction Conditions

Reaction Steps

2.00 g (0.014 mol) of potassium carbonate, 24.4 g (0.76 mol) of methanol and 15.6 g (0.52 mol) of paraformaldehyde are initially charged and cooled to 0° C. At this temperature, within 30 min, 77.4 g (0.40 mol) of benzyltrimethylsilanylmethylamine are metered in. The biphasic reaction mixture is stirred at 0° C. for a further 1 h and then warmed to room temperature within 20 min. Within 1 min, 190.9 g of pentane are metered in. The biphasic reaction mixture is separated and the upper organic phase is dried azeotropically for 2 h. The organic phase is concentrated and then fractionally distilled. Yield 74.9 g (79%) of a colorless liquid.

Provenance & Evidence