4-Bromo-m-cresol → 5-(4-Bromo-3-methyl-phenoxymethyl)-1-(2,6-dichloro-phenyl)-4-isopropyl-1H-pyrazole

HRID 2261747Notes

Reaction equation

HRID 2261747 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]1[C:13]([CH2:14][O:15][C:16]2[CH:21]=[CH:20][C:19](N)=[C:18]([CH3:23])[CH:17]=2)=[C:12]([CH:24]([CH3:26])[CH3:25])[CH:11]=[N:10]1.ClC1C=CC=C(Cl)C=1N1C(CO)=C(C(C)C)C=N1.[Br:45]C1C=CC(O)=CC=1C>>[Br:45][C:19]1[CH:20]=[CH:21][C:16]([O:15][CH2:14][C:13]2[N:9]([C:3]3[C:2]([Cl:1])=[CH:7][CH:6]=[CH:5][C:4]=3[Cl:8])[N:10]=[CH:11][C:12]=2[CH:24]([CH3:26])[CH3:25])=[CH:17][C:18]=1[CH3:23]

Participants

4

Reactant 3

HCID 728574-Bromo-m-cresolHCID 57443256(1-(2,6-dichlorophenyl)-4-isopropyl-1H-pyrazol-5-yl)methanolHCID 675278794-[2-(2,6-Dichloro-phenyl)-4-isopropyl-2H-pyrazol-3-ylmethoxy]-2-methyl-phenylamine

Product 1

HCID 675277775-(4-Bromo-3-methyl-phenoxymethyl)-1-(2,6-dichloro-phenyl)-4-isopropyl-1H-pyrazole

Procedure

The title compound is prepared essentially according to the preparation of 4-[2-(2,6-Dichloro-phenyl)-4-isopropyl-2H-pyrazol-3-ylmethoxy]-2-methyl-phenylamine using [2-(2,6-dichloro-phenyl)-4-isopropyl-2H-pyrazol-3-yl]-methanol and 4-bromo-3-methyl-phenol. ES/MS m/e 454.9 (M+1).

Sources & evidence

ORD record
ord-b86758bb780942509b576661582a4b61
Source dataset
uspto-grants-2010_12
Patent number
US07846960B2

Reaction notes

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