Ethyl 2-chloroacetoacetate → Ethyl 2-(4-methoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate

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Reaction Steps

A mixture of 4-methoxy-thiobenzamide (5 g, 30 mmol) and 2-chloro-3-oxo-butyric acid ethyl ester (4.6 mL, 33 mmol) in ethanol is stirred under reflux overnight. The reaction mixture is concentrated and the residue is triturated with ether to give the title compound as a yellow solid (5.8 g, 70%). LC-ES/MS m/e 278 (M+1)

Provenance & Evidence