2-Benzyloxy-4-formyl-benzoic acid methyl ester → Methyl 4-formyl-2-methylbenzoate

HRID 2261795Notes

Reaction equation

HRID 2261795 reaction equation
COC(=O)C1C=CC(C=O)=CC=1OCC1C=CC=CC=1.[CH3:21][O:22][C:23](=[O:36])[C:24]1[CH:29]=[CH:28][C:27]([CH:30]=[O:31])=[CH:26][C:25]=1[C:32](F)(F)F.COC(=O)C1C=C(C(F)(F)F)C=C(C=O)C=1>>[CH3:21][O:22][C:23](=[O:36])[C:24]1[CH:29]=[CH:28][C:27]([CH:30]=[O:31])=[CH:26][C:25]=1[CH3:32]

Participants

4

Reactant 3

HCID 574433112-Benzyloxy-4-formyl-benzoic acid methyl esterHCID 57443312Methyl 4-formyl-2-(trifluoromethyl)benzoateHCID 57443313Methyl 3-formyl-5-(trifluoromethyl)benzoate

Product 1

HCID 20134203Methyl 4-formyl-2-methylbenzoate

Procedure

Preparation 84A: 2-Benzyloxy-4-formyl-benzoic acid methyl ester (384 mg, 86%), LC-ES/MS m/e 293.0 (M+23); Preparation 84B: 4-Formyl-2-trifluoromethyl-benzoic acid methyl ester (1.29 g, 92%), LC-ES/MS m/e 233.3 (M+1); Preparation 84C: 3-Formyl-5-trifluoromethyl-benzoic acid methyl ester (0.5 g, 78%), 1HNMR (CDCl3) (ppm): 3.95 (3H, s), 8.25 (1H, s), 8.5 (1H, s), 8.7 (1H, s), 10.1 (1H, s).

Sources & evidence

ORD record
ord-b82cfdb05f9a4011960039d3363d1cef
Source dataset
uspto-grants-2010_12
Patent number
US07846960B2

Reaction notes

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