2-Butoxy-4-formyl-benzoic Acid Methyl Ester → 2-Butoxy-4-({[4-(tert-butyl-dimethyl-silanyloxy)-2-methyl-phenyl]-methyl-amino}-methyl)-benzoic Acid Methyl Ester

HRID 2261813Notes

Reaction equation

HRID 2261813 reaction equation
[CH3:1][O:2][C:3](=[O:29])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][N:11]([C:13]2[CH:18]=[CH:17][C:16]([O:19][Si:20]([C:23]([CH3:26])([CH3:25])[CH3:24])([CH3:22])[CH3:21])=[CH:15][C:14]=2[CH3:27])[CH3:12])=[CH:6][C:5]=1C.C([Si](C)(C)[O:35][C:36]1C=C[C:39](NC)=[C:38](C)[CH:37]=1)(C)(C)C.COC(=O)C1C=CC(C=O)=CC=1OCCCC>>[CH3:1][O:2][C:3](=[O:29])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][N:11]([C:13]2[CH:18]=[CH:17][C:16]([O:19][Si:20]([C:23]([CH3:26])([CH3:25])[CH3:24])([CH3:21])[CH3:22])=[CH:15][C:14]=2[CH3:27])[CH3:12])=[CH:6][C:5]=1[O:35][CH2:36][CH2:37][CH2:38][CH3:39]

Participants

4

Reactant 3

HCID 574433192-Butoxy-4-formyl-benzoic Acid Methyl EsterHCID 667041204-[(tert-butyldimethylsilyl)oxy]-N,2-dimethylanilineHCID 667041694-({[4-(Tert-butyl-dimethyl-silanyloxy)-2-methyl-phenyl]-methyl-amino}-methyl)-2-methyl-benzoic acid methyl ester

Product 1

HCID 667041812-Butoxy-4-({[4-(tert-butyl-dimethyl-silanyloxy)-2-methyl-phenyl]-methyl-amino}-methyl)-benzoic Acid Methyl Ester

Procedure

The title compound is prepared essentially according to the preparation of 4-({[4-(tert-butyl-dimethyl-silanyloxy)-2-methyl-phenyl]-methyl-amino}-methyl)-2-methyl-benzoic acid methyl ester starting from [4-(tert-butyl-dimethyl-silanyloxy)-2-methyl-phenyl]-methyl-amine and 2-butoxy-4-formyl-benzoic acid methyl ester. The title compound is obtained as syrup after workup and is used without further purification. LC-ES/MS m/e 472.3 (M+1).

Workup

  1. customThe title compound is prepared essentially

Sources & evidence

ORD record
ord-42df8359188c4920b1ed35d6d39feda2
Source dataset
uspto-grants-2010_12
Patent number
US07846960B2

Reaction notes

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