反应详情

温度

2.5 °C

6.0 g of trans-2-[4-(4-chlorophenyl)cyclohexyl]-3-chloro-1,4-naphthoquinone (trans-isomer of Formula IV) as obtained in Example 3 was suspended in 120 ml methanol. 6.0 g sodium hydroxide dissolved in 60 ml water was added drop-wise to the suspension under heating over a period of 20 minutes. Further, it was refluxed for 45 minutes and cooled to 0-5° C. and filtered. The filtrate was acidified with 50% aqueous hydrochloric acid to precipitate the product. The precipitated product was filtered, and recrystallized from acetonitrile to obtain 4 g (70% yield) atovaquone.

1. additionwas added drop-wise to the suspension
2. temperatureunder heating over a period of 20 minutes
3. temperatureFurther, it was refluxed for 45 minutes
4. filtrationfiltered
5. customto precipitate the product
6. filtrationThe precipitated product was filtered
7. customrecrystallized from acetonitrile