反应详情

115.8 g of 2-[4-(4-chlorophenyl)cyclohexyl]-2,3-dichloro-2,3-dihydro-1,4-naphthoquinone (Formula III) obtained in Example 6 was suspended in glacial acetic acid (926 ml). 33.77 g anhydrous sodium acetate was then added to the mixture and heated to reflux for 1 hour. After which, the mixture was cooled. Water was then added. The precipitated product was filtered of and recrystallized from acetonitrile to obtain 94.5 g (89.34% yield) of the trans-isomer of the compound of Formula IV.

1. temperatureheated
2. temperatureto reflux for 1 hour
3. temperatureAfter which, the mixture was cooled
4. filtrationThe precipitated product was filtered of and
5. customrecrystallized from acetonitrile