反应详情

温度

31 °C

The residue obtained (Formula IV) was suspended in 4.5 liter methanol. A solution of potassium hydroxide (225 gm) in water (1550 ml) was added drop-wise under heating over a period of one hour. The reaction mass was then refluxed for 2 hours and cooled to 30-32° C. and filtered. The filtrate was neutralized with 50% aqueous hydrochloric acid to precipitate atovaquone in a cis/trans-isomeric mixture (116 gm).

1. temperatureunder heating over a period of one hour
2. temperatureThe reaction mass was then refluxed for 2 hours
3. filtrationfiltered
4. customto precipitate atovaquone in a cis/trans-isomeric mixture (116 gm)