1,2-Dichloroethane → HCID 72483009, compound

Participants

Reaction Steps

To a slurry of 3-(5-{1-[(tert-butoxycarbonyl)amino]-1-methyl-2-phenylethyl}-1,3,4-oxadiazol-2-yl)-5-[methyl(methylsulfonyl)amino]benzoic acid (Intermediate VI) (0.303 g, 0.571 mmol) and Weinreb amine hydrochloride (0.111 g, 1.142 mmol) in 6 mL CHCl3 was added diisopropylethylamine (0.150 mL, 0.857 mmol), followed by EDC (0.154 g, 0.857 mmol) and HOAt (0.035 g, 0.228 mmol) After 7 days at rt, the reaction was quenched by the addition of brine. The layers were separated, the aqueous washed with CH2Cl2 (2×), the combined organics were washed with brine, dried over Na2SO4, filtered and concentrated. Purification with normal phase chromatography (40->100% EA/hex) afforded tert-butyl[1-(5-{3-{[methoxy(methyl)amino]carbonyl}-5-[methyl(methylsulfonyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)-1-methyl-2-phenylethyl]carbamate as a white foam. 1H NMR (CDCl3, 400 MHz) 8.21 (app t, J=1.5 Hz, 1H), 8.11 (app t, J=2.0 Hz, 1H), 7.90 (app t, J=1.5 Hz, 1H), 7.30-7.22 (m, 3H), 7.06-7.04 (m, 2H), 5.04 (br s, 1H), 3.60 (s, 3H), 3.42 (s, 3H), 3.39 (s, 3H), 2.90 (s, 3H), 1.69 (s, 3H), 1.41 (s, 9H). LCMS [M+H]+=574.

Provenance & Evidence