Methanol → Methyl 3-bromo-5-nitrobenzoate

Participants

Reaction Steps

To a solution of 3-bromo-5-nitrobenzoic acid (1.26 g, 5.12 mmol) in 20 mL MeOH was added thionyl chloride (0.410 mL, 5.63 mmol) dropwise via syringe. The reaction was heated to reflux for 15 h, cooled to rt and concentrated to afford a white solid. 1H NMR (CDCl3) δ 8.77 (m, 1H), 8.53 (m, 1H), 8.47 (m, 1H), 3.98 (s, 3H).

Provenance & Evidence