Hydrochloric Acid → HCID 68707858, compound

Participants

Reaction Steps

Anhydrous HCl was bubbled into a stirred solution of tert-butyl (2R)-2-ethynylpyrrolidine-1-carboxylate (0.71 g, 3.4 mmol) in ethyl acetate (15 mL) at 0° C. and allowed to mix for 45 min. Upon completion of the reaction as visualized by TLC (99:1 CH2Cl2 to MeOH), the solution was dried in vacuo to yield 2-prop-1-ynylpyrrolidinium chloride. LC-MS m/z=111. 1H NMR (CD3OD, 400 Mhz) 4.33-4.31 ppm (m, 1H), 3.42-3.24 (m, 2H), 2.36-1.99 (m, 4H), 1.88 (s, 3H).

Provenance & Evidence