Triethylamine → HCID 86615676, compound

Participants

Reaction Steps

A solution of (R)-2-tert-butoxycarbonylamino-2-methyl-3-phenylpropanal (80 mg, 0.30 mmol), hydroxylamine hydrochloride (25 mg, 0.36 mmol) and triethylamine (0.125 mL, 0.9 mmol) in 3.4 mL ethanol was heated to reflux temperature overnight. Additional hydroxylamine hydrochloride (25 mg, 0.36 mmol) and triethylamine (0.125 mL, 0.9 mmol) were added and the reaction continued at reflux temperature for 4.5 h. Concentration and flash chromatography (0-25% EtOAc/hexanes) gave (R)-2-tert-butoxycarbonylamino-2-methyl-3-phenylpropanal oxime. 1H NMR (CDCl3) δ 7.95 (bs, 1H), 7.52 (bs, 1H), 7.25 (m, 3H), 7.10 (d, J=6.7 Hz, 2H), 5.01 (s, 1H), 3.14 (m, 2H), 1.46 (s, 9H), 1.42 (s, 3H).

Provenance & Evidence