Tetrahydrofuran → HCID 11563265, compound

Participants

Reaction Steps

To a solution of 0.013 g (0.027 mmol) 3-(4-acetyl-1H-1,2,3-triazol-1-yl)-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[(methylsulfonyl)(propyl)amino]benzamide in 1 mL THF at 0° C. was added 0.3 mL (approx. 0.06 mmol) benzyllithium in ether. After 30 min, another 0.3 mL benzyllithium was added and after a further 30 min the reaction mixture was quenched with 10 mL saturated NH4Cl, extracted w. 20 mL EtOAc, washed with 10 mL brine, dried over MgSO4, filtered, and concentrated. Purification by preparative HPLC (5->95% CH3CN/H2O over 30 min, 0.1% added TFA, C18 PRO YMC 20×150 nm) afforded 2 mg N-[(1R)-1-(4-fluorophenyl)ethyl]-3-[4-(1-hydroxy-1-methyl-2-phenylethyl)-1H-1,2,3-triazol-1-yl]-5-[(methylsulfonyl)(propyl)amino]benzamide as a white solid. NMR 1H NMR (CDCl3) δ 8.06 (s, 1H), 7.82 (m, 3H), 7.39 (m, 2H) 7.30 (m, 1H), 7.24 (m, 2H), 7.06 (m, 4H), 6.59 (br d, J=7.14 Hz, 1H), 5.30 (m, 1H), 3.71 (t, J=7.14 Hz, 2H), 3.34 (br d, J=13 Hz, 1H), 3.15 (m, 1H), 2.93 (s, 3H), 1.65 (m, 6H), 1.52 (m, 2H), 0.92 (t, J=7.33 Hz, 3H). High resolution mass spec (FT/ICR) calc M+H=580.2389 found 580.2400.

Provenance & Evidence