Trimethylaluminum → HCID 68704545, compound

Participants

Reaction Steps

To a 0° C. suspension of 0.03 g (0.05 mmol) 3-{4-[(1E)-N-(tert-butylsulfinyl)ethanimidoyl]-1H-1,2,3-triazol-1-yl}-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[(methylsulfonyl)(propyl)amino]benzamide in 5 mL toluene was added 0.1 mL (0.2 mmol, 2M solution in toluene) trimethylaluminum followed by 1 mL (approx. 0.2 mmol, 0.2 mM solution in ether) benzyllithium. The reaction mixture was stirred for 1 hr, then 0.4 mL more benzyllithium was added and the reaction mixture stirred for another hour at 0° C. The reaction was quenched by addition of 1 mL of saturated sodium sulfate solution and 50 mL EtOAc and stirred vigorously. To this was added MgSO4 and the resulting mixture was filtered through celite and concentrated. Purification by flash chromatography (1×8 cm silica gel, linear gradient 30-100% EtOAc/hexanes) afforded 8 mg 3-(4-{1-[(tert-butylsulfinyl)amino]-1-methyl-2-phenylethyl}-1H-1,2,3-triazol-1-yl)-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[(methylsulfonyl)(propyl)amino]benzamide which was dissolved in 1 mL methanol. To this was added 0.7 mL 2M HCl in ether. After 30 minutes the mixture was concentrated and purified by preparative HPLC (5->95% CH3CN/H2O over 30 min, 0.1% added TFA, C18 PRO YMC 20×150 mm) to afford 3 mg 3-[4-(1-amino-1-methyl-2-phenylethyl)-1H-1,2,3-triazol-1-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[(methylsulfonyl)(propyl)amino]benzamide as its trifluoroacetate salt. 1H NMR (CD3OD, 500 MHz) δ 8.55 (s, 1H), 8.28 (s, 1H), 8.04 (s, 1H), 7.99 (m, 1H), 7.42 (m, 2H), 7.26 (m, 3H), 7.07 (m, 2H), 7.00 (m, 2H), 5.25 (m, 1H), 3.77 (t, J=6.83 Hz, 2H), 3.47 (d, J=13 Hz, 1H), 3.27 (d, J=13 Hz, 1H), 3.01 (s, 3H), 1.76 (s, 3H), 1.59 (d, J=7.18 Hz, 3H), 1.53 (m, 2H), 0.95 (t, J=7.33 Hz, 3H). High resolution mass spec (FT/ICR) calc M+H=579.2548 found 578.2560.

Provenance & Evidence