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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 22620Erstellt: 25. Oktober 2026

tert-Butoxy bis(dimethylamino)methane → 4-(3-Dimethylamino-2-phenyl-acryloyl)-1H-pyrrole-2-carboxylic acid benzylamide

https://huagongshe.com/reaction/22620

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukttert-Butoxy bis(dimethylamino)methaneHCID 79885—
Edukt4-Phenylacetyl-1H-pyrrole-2-carboxylic acid benzylamideHCID 12125417—
LösungsmittelTetrahydrofuranHCID 8028—
Produkt4-(3-Dimethylamino-2-phenyl-acryloyl)-1H-pyrrole-2-carboxylic acid benzylamideHCID 69426886—

Reaktionsschritte

To a solution of compound 2 (1 equivalent) in THF, at ambient temperature, was added (Me2N)2CHOt-Bu (3 equivalents). After 24 hours, the solvent was evaporated and the crude product 3 was utilized without purification. 1H NMR (CDCl3) □4.4 (s, 2H), 4.8 (s, NH), 6.8-7.4 (m, 13H).

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS06849267B2
Quelldatensatzuspto-grants-2005_02
ORD IDord-3c9b471365bf49f697c09710436f04f8
Quellennotizuspto-grants-2005_02