Methyl 2-[(4-amino-3-nitrophenyl)carbonyl]benzoate → Methyl 2-[(3,4-diaminophenyl)carbonyl]benzoate

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Reaction Steps

A solution of methyl 2-[(4-amino-3-nitrophenyl)carbonyl]benzoate (420 mg, 1.39 mmol) in a mixture of terahydrofuran-ethyl acetate (1:1, 20 mL) was hydrogenated over 10% Pd—C (10 mg) for 18 h. The catalyst removed by filtration and the filtrate concentrated to give methyl 2-[(3,4-diaminophenyl)carbonyl]benzoate (370 mg, 98%) as a brown powder. MS (EI) for C15H14N2O3: 293 (M+Na).

Provenance & Evidence