Methoxyacetyl chloride → N-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-2-methoxyacetamide

HRID 2262045Notes

Reaction equation

[Cl:1][C:2]1[N:3]=[C:4]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:5]2[S:10][C:9]([NH2:11])=[CH:8][C:6]=2[N:7]=1.[CH3:18][O:19][CH2:20][C:21](Cl)=[O:22]>>[Cl:1][C:2]1[N:3]=[C:4]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:5]2[S:10][C:9]([NH:11][C:21](=[O:22])[CH2:20][O:19][CH3:18])=[CH:8][C:6]=2[N:7]=1

Participants

Reactant 2

HCID 96623Methoxyacetyl chloride

HCID 595928682-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-amine

Product 1

HCID 86618373N-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-2-methoxyacetamide

Procedure

55 mg of 2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-amine was reacted with 26 mg of methoxyacetyl chloride via General Procedure G to give N-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-2-methoxyacetamide.

Sources & evidence

ORD record: ord-721f2f7f48334722b200973b61f17b83
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07846929B2

Reaction notes

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