Acetyl chloride → N-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)acetamide

HRID 2262083Notes

Reaction equation

[Cl:1][C:2]1[N:3]=[C:4]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:5]2[S:10][C:9]([NH2:11])=[CH:8][C:6]=2[N:7]=1.[C:18](Cl)(=[O:20])[CH3:19]>>[Cl:1][C:2]1[N:3]=[C:4]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:5]2[S:10][C:9]([NH:11][C:18](=[O:20])[CH3:19])=[CH:8][C:6]=2[N:7]=1

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 595928682-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-amine

Product 1

HCID 86618388N-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)acetamide

Procedure

2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-amine (40 mg) was reacted with 21 μL of acetyl chloride via General Procedure G to give N-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)acetamide.

Sources & evidence

ORD record: ord-74a7d79bb8d1402b9464dee8411f88cf
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07846929B2

Reaction notes

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