Benzoyl chloride → N-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)benzamide

HRID 2262087Notes

Reaction equation

[Cl:1][C:2]1[N:3]=[C:4]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:5]2[S:10][C:9]([NH2:11])=[CH:8][C:6]=2[N:7]=1.[C:18](Cl)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[Cl:1][C:2]1[N:3]=[C:4]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:5]2[S:10][C:9]([NH:11][C:18](=[O:25])[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[CH:8][C:6]=2[N:7]=1

Participants

Reactant 2

HCID 7412Benzoyl chloride

HCID 595928682-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-amine

Product 1

HCID 86618390N-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)benzamide

Procedure

2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-amine (35 mg) was reacted with 30 μL of benzoyl chloride via General Procedure G to give N-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)benzamide.

Sources & evidence

ORD record: ord-fa5af6e681734a7da56b20c6e1f1d667
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07846929B2

Reaction notes

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